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陈磊

时间:2017-06-10 18:13:54  点击:   发布者:skyJX

陈磊:讲师

学 历:理学博士

专 业:细胞生物学

实验室:生物楼310

联系方式:0376-6391380;chenl_6789@163.com

教育经历

2002-2006 三峡大学生物学,学士

2006-2009 三峡大学生物学,硕士

2009-2013 中国科学院遗传与发育生物学研究所,博士

工作经历

2013-今 信阳师范学院威廉希尔中文网站

教学情况:
主讲《细胞生物学专题》和《分子生物学》等本科生课程。
研究领域:

 

1.乳腺癌干细胞三维培养体系建立;

2.注射型胶原支架材料的制备;

3.有序性胶原支架材料应用于脊髓损伤修复。

获资助项目:
参与国家自然科学基金面上项目。
代表性论文和著作:

* 表示通讯作者

1. Zhengquan He,Lei Chen, Wei Yao,Jianwu Dai.Recent Progress in Cucumber (Cucumis sativus) Transformation. Transgenic Plant Journal,2008,2: 39-44 (co-first-author).
2. Lei Chen, Zhengquan He,Bing Chen, Yannan Zhao,Wenjie Sun, Zhifeng Xiao, Jing Zhang, Maojin Yang, Zhiying Gao, and Jianwu Da. Direct Chemical Cross-Linking of Platelet-Derived Growth Factor-BB to the Demineralized Bone Matrix Improves Cellularization and Vascularization. Biomacromolecules, 2009, 10, 3193–3198 (IF=5.479).
3. Lei Chen, Zhengquan He, Bing Chen, Maojin Yang, Yannan Zhao, Wenjie Sun, Zhifeng Xiao, Jing Zhang, Jianwu Dai. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci: Mater Med, 2010, 21:309–317(IF=2.316).
4. Lei Chen, Zhifeng Xiao, Yue Meng, Yannan Zhao, Jin Han, Guannan Su, Bing Chen, Jianwu Dai. The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs. Biomaterials, 2012, 33: 1437-1444(IF=7.404).
5. 陈磊,何正权,杨晔,姚伟. 植物遗传转化的正向选择标记. 中国生物工程杂志,2008,28(6s):283-288.
6. Jin Han, Zhifeng Xiao, Lei Chen, Bing Chen, Xiaoran Li, Sufang Han, Yannan Zhao, Jianwu Dai. Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway. Biomaterials. 2013, 34(8):1921-8.
7. Qin Shi,Yang Li,Jie Sun, Hua Zhang,Lei Chen, Bing Chen, Huilin Yang, Zhaoxu Wang. The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2. Biomaterials. 2012, 33(28): 6644–6649
8. Qianqian Han, Wei Jin, Zhifeng Xiao, Hongbin Ni, Jinhuan Wang, Jie Kong, Jun Wu, Weibang Liang, Lei Chen, Yannan Zhao, Bing Chen, Jianwu Dai. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Biomaterials. 2010, 31(35): 9212–9220
9. Qifen He, Yannan Zhao, Bing Chen, Zhifeng Xiao, Jing Zhang, Lei Chen, Wei Chen, Feilong Deng, Jianwu Dai. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor. Acta Biomaterialia. 2011, 7(3):1084–1093
10. Guannan Su, Yannan Zhao, Jianshu Wei, Jin Han, Lei Chen, Zhifeng Xiao, Bing Chen, Jianwu Dai.The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials.2013, 34(13):3215–3222
11. Sufang Han, Yannan Zhao, Zhifeng Xiao, Jin Han, Bing Chen, Lei Chen, Jianwu Dai.The Three-Dimensional Collagen Scaffold Improves the Stemness of Rat Bone Marrow Mesenchymal Stem Cells. Journal of Genetics and Genomics. 2012, 39(12): 633–641
12. Xiaoran Li, Zhifeng Xiao, Jin Han, Lei Chen, Hanshan Xiao, Fukai Ma, Xianglin Hou, Xing Li, Jie Sun, Wenyong Ding, Yannan Zhao, Bing Chen, Jianwu Dai. Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials, 2013, 34(21): 5107–5116.
13. Jian Guan, Zhaohui Zhu, Robert Chunhua Zhao, Zhifeng Xiao, Chenxi Wu, Qin Han, Lei Chen, Weimin Tong, Jin Zhang, Qianqian Han, Jun Gao, Ming Feng, Xinjie Bao, Jianwu Dai, Renzhi Wang. Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats. Biomaterials, 2013, 34(24): 5937–5946.
14. Jin Han, Lei Chen, Guanzheng Luo, Bin Dai, Xiujie Wang, Jianwu Dai. Three-dimensional culture may promote cell reprogramming. Organogenesis,2013,9(2):118-120
15. Guannan Su, Yannan Zhao, Jianshu Wei, Zhifeng Xiao, Bing Chen, Jin Han, Lei Chen, Jian Guan, Renzhi Wang, Qun Dong, Jianwu Dai. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials, 2013, 34(24): 5897–5906

 

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